Determination of Domain Structure of Proteins from X-Ray Solution Scattering

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Determination of domain structure of proteins from X-ray solution scattering.

An ab initio method for building structural models of proteins from x-ray solution scattering data is presented. Simulated annealing is employed to find a chain-compatible spatial distribution of dummy residues which fits the experimental scattering pattern up to a resolution of 0.5 nm. The efficiency of the method is illustrated by the ab initio reconstruction of models of several proteins, wi...

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New methods for domain structure determination of proteins from solution scattering data

Author(s) of this paper may load this reprint on their own web site provided that this cover page is retained. Republication of this article or its storage in electronic databases or the like is not permitted without prior permission in writing from the IUCr. New approaches for domain structure determination of macromolecules from X-ray solution scattering are presented. An ab initio method for...

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ژورنال

عنوان ژورنال: Biophysical Journal

سال: 2001

ISSN: 0006-3495

DOI: 10.1016/s0006-3495(01)76260-1